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Stories about plagues run the gamut from “Oedipus Rex” to “Angels in America.” “You are the plague,” a blind man tells Oedipus. “It’s 1986 and there’s a plague, friends younger than me are dead, and I’m only thirty,” a Tony Kushner character says. There are plagues here and plagues there, from Thebes to New York, horrible and ghastly, but never one plague everywhere, until Mary Shelley decided to write a follow-up to “Frankenstein.”

“The Last Man,” which is set in the twenty-first century, is the first major novel to imagine the extinction of the human race by way of a global pandemic. Shelley published it at the age of twenty-nine, after nearly everyone she loved had died, leaving her, as she put it, “the last relic of a beloved race, my companions, extinct before me.” The book’s narrator begins as a poor and uneducated English shepherd: primitive man, violent and lawless, even monstrous. Cultivated by a nobleman and awakened to learning—“An earnest love of knowledge . . . caused me to pass days and nights in reading and study”—he is elevated by the Enlightenment and becomes a scholar, a defender of liberty, a republican, and a citizen of the world.

Then, in the year 2092, the plague arrives, ravaging first Constantinople. Year after year, the pestilence dies away every winter (“a general and never-failing physician”), and returns every spring, more virulent, more widespread. It reaches across mountains, it spreads over oceans. The sun rises, black: a sign of doom. “Through Asia, from the banks of the Nile to the shores of the Caspian, from the Hellespont even to the sea of Oman, a sudden panic was driven,” Shelley wrote. “The men filled the mosques; the women, veiled, hastened to the tombs, and carried offerings to the dead, thus to preserve the living.” The nature of the pestilence remains mysterious. “It was called an epidemic. But the grand question was still unsettled of how this epidemic was generated and increased.” Not understanding its operation and full of false confidence, legislators hesitate to act. “England was still secure. France, Germany, Italy and Spain, were interposed, walls yet without a breach, between us and the plague.” Then come reports of entire nations, destroyed and depopulated. “The vast cities of America, the fertile plains of Hindostan, the crowded abodes of the Chinese, are menaced with utter ruin.” The fearful turn to history too late, and find in its pages, even in the pages of the Decameron, the wrong lesson: “We called to mind the plague of 1348, when it was calculated that a third of mankind had been destroyed. As yet western Europe was uninfected; would it always be so?” It would not always be so. Inevitably, the plague comes, at last, to England, but by then the healthy have nowhere left to go, because, in the final terror of pandemic, there is “no refuge on earth”: “All the world has the plague!”

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